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METHYL (1S,2S)-1-BENZYL-3-CHLORO-2-HYDROXYPROPYLCARBAMATE synthesis

4synthesis methods
Carbamic acid, [(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-, methyl ester (9CI)

176972-61-5
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METHYL (1S,2S)-1-BENZYL-3-CHLORO-2-HYDROXYPROPYLCARBAMATE

176972-62-6
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inquiry

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Yield:90 % de

Reaction Conditions:

with potassium phosphate;alcohol dehydrogenase from Lactobacillus brevis;isopropyl alcohol;NADPH in water;dimethyl sulfoxide at 30; pH=7.5; for 24 h;Enzymatic reaction;diastereoselective reaction;

References:

De Miranda, Amanda S.;Simon, Robert C.;Grischek, Barbara;De Paula, Gabriel C.;Horta, Bruno A. C.;De Miranda, Leandro S. M.;Kroutil, Wolfgang;Kappe, C. Oliver;De Souza, Rodrigo O. M. A. [ChemCatChem,2015,vol. 7,# 6,p. 984 - 992]