BENZOIC ACID,3-BROMO-2-HYDROXY-5-METHYL-,METHYL ESTER synthesis

Yield:17746-77-9 100 %

Reaction Conditions:

with bromine;sodium acetate in acetic acid at 20;

Steps:

Intermediate 24: Methyl 3-bromo-2-hydroxy-5-methyl-benzoate

Bromine (1.0 g, 6.3 mmol) was added to a stirred mixture of methyl 2-hydroxy-5- methylbenzoate (1.0 g, 0.87 mL, 6.0 mmol) and sodium acetate (0.74 g, 9.0 mmol) in AcOH (5 mL) at rt. After 15 min, added water (20 mL) and filtered. The solids were washed with water (5 mL) and assumed quantitative yield. MS ES+ m/z 245,247 [M+H]⁺.

References:

WO2022/235574,2022,A1 Location in patent:Paragraph 523; 524