Benzenebutanoic acid, 4-carboxy-, -alpha--ethyl ester (9CI) synthesis
- Product Name:Benzenebutanoic acid, 4-carboxy-, -alpha--ethyl ester (9CI)
- CAS Number:177736-21-9
- Molecular formula:C13H16O4
- Molecular Weight:236.26
177736-20-8
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177736-21-9
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Yield:177736-21-9 84%
Reaction Conditions:
in isopropyl alcohol;acetone;
Steps:
31 31G 4-(3-Ethoxycarbonylpropyl)benzoic acid
31G 4-(3-Ethoxycarbonylpropyl)benzoic acid 1 ml of Jones's reagent was added at 0°C to a solution of ethyl 4-(4-formylphenyl)butanoate (1.16 g, 5.29 mmol) in acetone (7 ml). The reaction mixture was stirred at room temperature for 18 h, then added with isopropanol (1 ml) and extracted with ethyl ether. The organic phase was dried and the solvent was evaporated off, to obtain 1.05 g of the title compound as a colourless oil (84% yield). 1H N.M.R. (300 MHz, CDCl3) δ ppm: 1.09 (t, 3H); 1.81 (m, 2H); 2.17 (t, 2H); 2.55 (t, 2H); 3.97 (q, 2H); 7.11 (d, 2H); 7.87 (d, 2H); 9.11 (m, 1H).
References:
EP775133,2001,B1
623-73-4
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$27.30/25ML
1075-49-6
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$17.00/1g
177736-21-9
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