ChemicalBook CAS DataBase List Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester

Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester synthesis

6synthesis methods

Product Name:Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester
CAS Number:178306-47-3
Molecular formula:C17H18O4
Molecular Weight:286.32

67-56-1 Synthesis

67-56-1
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3,3-DIPHENYL-OXIRANE-2-CARBOXYLIC ACID METHYL ESTER

76527-25-8
56 suppliers
$140.00/100mg

Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester

178306-47-3
154 suppliers
$60.00/500mg

Yield:178306-47-3 88%

Reaction Conditions:

with boron trifluoride diethyl etherate at 0 - 20; for 14 h;

Steps:

1 Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropionate
5 g (19.6 mmol) of methyl 3,3-diphenyl-2,3-epoxypropionate,Was dissolved in 50 ml of anhydrous methanol,0.1 ml of boron trifluoride etherate was added at 0 ° C.The mixture was stirred at 0 ° C. for 2 hours,The mixture was further stirred at room temperature for 12 hours.The solvent was distilled off, The residue was placed in ethyl acetate,Washed with sodium bicarbonate and water,And dried over magnesium sulfate.After removing the solvent by distillation,5.5 g (88%) of a pale yellow oil remained.

References:

ABBVIE DEUTSCHLAND GMBH & CO. KG;RIECHERS, HARTMUT;KLINGE, DAGMAR;AMBERG, WILHELM;KLING, ANDREAS;MULLER, STEFAN;BAUMANN, ERNST;RHEINHEIMER, JOACHIM;VOGELBACHER, UWE JOSEF;WERNET, WOLFGANG;UNGER, LILIANE;RASCHACK, MANFRED JP5700378, 2015, B2 Location in patent:Paragraph 0062

FullText

76527-25-8
56 suppliers
$140.00/100mg

178306-47-3
154 suppliers
$60.00/500mg

References

119-61-9 Synthesis