METHYL 3-(((PHENYLCARBONYLAMINO)THIOXOMETHYL)AMINO)THIOPHENE-2-CARBOXYLATE synthesis
- Product Name:METHYL 3-(((PHENYLCARBONYLAMINO)THIOXOMETHYL)AMINO)THIOPHENE-2-CARBOXYLATE
- CAS Number:178675-17-7
- Molecular formula:C14H12N2O3S2
- Molecular Weight:320.39
22288-78-4
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$11.00/5g
532-55-8
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178675-17-7
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$122.00/1g
Yield:178675-17-7 90%
Reaction Conditions:
in acetonitrile at 20; for 12 h;
Steps:
1 Preparation of methyl 3-(3-benzoylthioureido)thiophene-2-carboxylate
methyl 3-aminothiophene-2-carboxylate of formula a 100 g (0.64 mol) ofWas added to 1 L of acetonitrile,114 g (0.70 mol) of benzoylisothiocyanate were added, And the mixture was stirred at room temperature for 12 hours. After completion of the reaction, the reaction mixture was cooled to 5°C and stirred for 1 hour.The resulting solid was filtered,And dried to obtain 183 g (yield: 90%) of the title compound of the formula (2).
References:
KR2016/38615,2016,A Location in patent:Paragraph 0049; 0050