![](/CAS/GIF/179089-69-1.gif)
(7S,9AS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol synthesis
- Product Name:(7S,9AS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol
- CAS Number:179089-69-1
- Molecular formula:C9H18N2O
- Molecular Weight:170.25
![(7S,9aS)-tert-Butyl 7-(hydroxymethyl)hexahydro-1H-pyrido[1,2-a]pyrazine-2(6H)-carboxylate](/CAS/GIF/156856-50-7.gif)
156856-50-7
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![(7S,9AS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol](/CAS/GIF/179089-69-1.gif)
179089-69-1
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Yield:179089-69-1 3.39 g (92%)
Reaction Conditions:
in water;trifluoroacetic acid;
Steps:
2 (7S,9aS)-7-Hydroxymethyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazin STR74
PREPARATION 2 (7S,9aS)-7-Hydroxymethyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazin STR74 A solution of 5.84 g (21.6 mmol) of (7S,9aS)-N-BOC-7-hydroxymethyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine (WO 93/25552) in 140 mL of trifluoroacetic acid and 60 mL of water was stirred at room temperature for 16 h. The mixture was concentrated and the residue dissolved in water. The aqueous phase saturated with solid sodium carbonate and extracted with chloroform (3*). The combined organic layers were dried (magnesium sulfate), filtered and evaporated to give 3.39 g (92%) of the title compound. This material was used without further purification for subsequent reactions. 13 C NMR (base, d-6 DMSO): δ 24.8, 25.1, 36.0, 45.7, 51.9, 56.1, 56.7, 62.0, 62.7.
References:
US5852031,1998,A