ChemicalBook CAS DataBase List Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-formyl-, methyl ester (9CI)

Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-formyl-, methyl ester (9CI) synthesis

7synthesis methods

Product Name:Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-formyl-, methyl ester (9CI)
CAS Number:180464-92-0
Molecular formula:C8H10O3
Molecular Weight:154.16

Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(hydroxymethyl)-, methyl ester (9CI)

180464-87-3
74 suppliers
$111.00/100mg

Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-formyl-, methyl ester (9CI)

180464-92-0
57 suppliers
$260.00/100mg

Yield:180464-92-0 96%

Reaction Conditions:

with pyridinium chlorochromate in dichloromethane at 20; for 2 h;

Steps:

79.1 1. Synthesis of Intermediate 79-1

To a solution of methyl 3-(hydroxymethyl)bicyclo[l.l.l]pentane-l-carboxylate (2.0 g, 12.81 mmol, 1.0 equiv) in DCM (68.0 mL) at r.t. were added PCC (4.1 g, 19.21 mmol, 1.5 equiv) in portions. The mixture was stirred at rt for 2 h, diluted with ether (180 mL), stirred for 20 min, filtered off the solid, concentrated under reduced pressure to afford 1.9 g (96%) of methyl 3-formylbicyclo[l.l.l]pentane-l-carboxylate (Intermediate 79-1) as a brown solid.

References:

WO2020/47447,2020,A1 Location in patent:Paragraph 0672

83249-10-9 Synthesis