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ChemicalBook CAS DataBase List 17,21-dihydroxypregn-4-ene-3,20-dione 17,21-di(acetate)
1807-15-4

17,21-dihydroxypregn-4-ene-3,20-dione 17,21-di(acetate) synthesis

10synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 7.46 g / p-toluenesulfonic acid / benzene / 7 h / Heating
3: 1.) 30percent HClO4, 2.) aq. ammonia / 1.) CH2Cl2, -5 to -4 deg C, 20 min, 2.) pH 7, 2 h

References:

Ryakhovskaya, M. I.;Popova, E. V.;Andryushina, V. A.;Grinenko, G. S. [Pharmaceutical Chemistry Journal,1990,vol. 24,# 11,p. 839 - 842][Khimiko-Farmatsevticheskii Zhurnal,1990,vol. 24,# 11,p. 55 - 57]