(S)-2-(tert-Butoxycarbonylamino)-4-(dimethylamino)butanoic acid synthesis

4synthesis methods

Product Name:(S)-2-(tert-Butoxycarbonylamino)-4-(dimethylamino)butanoic acid
CAS Number:181518-87-6
Molecular formula:C11H22N2O4
Molecular Weight:246.3

25691-37-6 Synthesis

25691-37-6
189 suppliers
$11.00/250mg

(S)-2-(tert-Butoxycarbonylamino)-4-(dimethylamino)butanoic acid

181518-87-6
14 suppliers
$312.00/250mg

Yield:-

Reaction Conditions:

with formaldehyd;hydrogen;acetic acid;palladium(II) hydroxide in methanol at 20;

Steps:

To a suspension Of Pd(OH)₂, (20%, 100 mg), aqueous formaldehyde (37% wt, 4 ml), acetic acid, (0,5 mL) in methanol (15 mL) was added (S)-4-amino-2~(tert- butoxycarbonylamino)butanoic acid (1 g, 4.48 mmol). The reaction was purged several times with hydrogen and was stirred overnight with an hydrogen balloon room temp. The reaction mixture was filtered through a pad of diatomaceous earth (CELITE), and the volatile component was removed in vacuo. The resulting crude material was used as is for the next step. LC/MS: Anal Calcd. for C j 1H22N2O₄: 246; found: 247 (M+H)⁺.

References:

WO2010/138488,2010,A1 Location in patent:Page/Page column 142

50-00-0 Synthesis

50-00-0
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25691-37-6 Synthesis

25691-37-6
189 suppliers
$11.00/250mg

181518-87-6
14 suppliers
$312.00/250mg

References

Butanoic acid, 4-(dimethylamino)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester, (2S)-

765914-80-5
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181518-87-6
14 suppliers
$312.00/250mg

References

76969-87-4 Synthesis

Methyl (S)-2-(Boc-aMino)-4-broMobutyrate

76969-87-4
36 suppliers
$64.00/100mg

181518-87-6
14 suppliers
$312.00/250mg

References