Aspidospermidine-3-carboxylic acid, 2,3-didehydro-, methyl ester, (±)- synthesis

4synthesis methods

Product Name:Aspidospermidine-3-carboxylic acid, 2,3-didehydro-, methyl ester, (±)-
CAS Number:18374-17-9
Molecular formula:C21H26N2O2
Molecular Weight:338.4433

62498-23-1
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methyl 2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylate

75837-23-9
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Aspidospermidine-3-carboxylic acid, 2,3-didehydro-, methyl ester, (±)-

18374-17-9
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Yield:18374-17-9 81.2%

Reaction Conditions:

Stage #1: 5-chloro-2-ethylpentanal;methyl 1-methyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-1-carboxylatewith toluene-4-sulfonic acid in toluene; for 100 h;Heating;
Stage #2: with 1,8-diazabicyclo[5.4.0]undec-7-ene in toluene; for 18 h;Heating;

References:

Belferdi, Fatiha;Belattar, Abdelhamid [Molecules,2001,vol. 6,# 10,p. 803 - 814]

1H-Indole-2-carboxylic acid, 3-(2-aminoethyl)-, ethyl ester, hydrochloride (1:1)

53590-32-2
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18374-17-9
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References

1H-Indole-2-methanol, 3-[2-[bis(phenylmethyl)amino]ethyl]-

146681-78-9
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18374-17-9
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References

1H-Indole-2-acetonitrile, 3-[2-[bis(phenylmethyl)amino]ethyl]-

146681-80-3
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18374-17-9
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References