ChemicalBook CAS DataBase List (3R,4R)-1-Benzyl-4-(trifluoromethyl)tetrahydro-1H-pyrrole-3-carboxylic acid

(3R,4R)-1-Benzyl-4-(trifluoromethyl)tetrahydro-1H-pyrrole-3-carboxylic acid synthesis

2synthesis methods

Product Name:(3R,4R)-1-Benzyl-4-(trifluoromethyl)tetrahydro-1H-pyrrole-3-carboxylic acid
CAS Number:184844-96-0
Molecular formula:C13H14F3NO2
Molecular Weight:273.25

93102-05-7 Synthesis

N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine

93102-05-7
295 suppliers
$6.00/1g

(3R,4R)-1-Benzyl-4-(trifluoromethyl)tetrahydro-1H-pyrrole-3-carboxylic acid

184844-96-0
10 suppliers
$370.00/500mg

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 95 percent / TFA / CH₂Cl₂
2: 92 percent / NaOH / methanol

References:

Fukui, Hideto;Shibata, Tetsuo;Naito, Takanobu;Nakano, Jun;Maejima, Tetsuro;Senda, Hisato;Iwatani, Wakao;Tatsumi, Yoshiyuki;Suda, Masahiro;Arika, Tadashi [Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,# 20,p. 2833 - 2838]

ethyl (3R,4R)-1-benzyl-4-(trifluoromethyl)pyrrolidine-3-carboxylate

152188-51-7
11 suppliers
inquiry

184844-96-0
10 suppliers
$370.00/500mg

References