2-(4-NITRO-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID synthesis
1synthesis methods
- Product Name:2-(4-NITRO-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID
- CAS Number:18627-60-6
- Molecular formula:C11H8N2O6
- Molecular Weight:264.19
Yield:18627-60-6 85.7%
Reaction Conditions:
with acetic acidReflux;
Steps:
4.4-a
4-a: 2-(3-nitro-phthalimide) propionic acid 3.90 g (20.2 mmol)3-nitrophthalic anhydride, alanine 2.20g (24.7mmol), glacial acetic acid 20mL, placed in 50mL reaction bottle, reflux to the remaining raw materials, let cool, pour 50mL cold water, precipitation of white solid, Filtration, washing with water and drying afforded 4.57 g of a white solid in 85.7% by weight yield.
References:
CN102786464,2016,B Location in patent:Paragraph 0072; 0074