2(1H)-Quinolinethione, 3,4-dihydro-7-methoxy-1-methyl- synthesis

1synthesis methods

Product Name:2(1H)-Quinolinethione, 3,4-dihydro-7-methoxy-1-methyl-
CAS Number:187680-06-4
Molecular formula:C11H13NOS
Molecular Weight:207.29

2(1H)-Quinolinethione, 3,4-dihydro-6-methoxy-1-methyl-

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22246-17-9 Synthesis

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2(1H)-Quinolinethione, 3,4-dihydro-7-methoxy-1-methyl-

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Yield:-

Steps:

21.i Preparation of (2S,3S)-3-[(7-Methoxy-1-methyl-2-thioxo-1,2,3,4-tetrahydroquinolin-6-yl) methyl]amino-2-phenylpiperidine Dihydrochloride (Compound 91)

(i). 7-Methoxy-1-methyl-2-thioxo-1,2,3,4-tetrahydroquinolin (Compound 88) This compound was prepared from compound 55 in a procedure analogous to that used to make compound 46. ¹H-NMR (270 MHz) δ (CDCl₃) 7.08 (1H, d, J=8.1 Hz), 6.71 (1H, d, J=2.6 Hz), 6.64 (1H, dd, J=8.1, 2.6 Hz), 3.89 (3H, s), 3.83 (3H, s), 3.23-3.14 (2H, m), 2.78-2.68 (2H, m) ppm.

References:

US2003/105124,2003,A1