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ChemicalBook CAS DataBase List 3-Amino-6-methoxy-benzo[b]thiophene-2-carboxylic acid methyl ester

3-Amino-6-methoxy-benzo[b]thiophene-2-carboxylic acid methyl ester synthesis

3synthesis methods
38469-83-9 Synthesis
4-METHOXY-2-NITROBENZONITRILE

38469-83-9
114 suppliers
$15.00/1g

2365-48-2 Synthesis
Methyl thioglycolate

2365-48-2
340 suppliers
$14.00/25g

-

Yield:189439-55-2 72%

Reaction Conditions:

with water;potassium hydroxide in 1,2-dimethoxyethane at -5 - 0; for 1 h;Inert atmosphere;

References:

Romagnoli, Romeo;Baraldi, Pier Giovanni;Kimatrai Salvador, Maria;Preti, Delia;Aghazadeh Tabrizi, Mojgan;Bassetto, Marcella;Brancale, Andrea;Hamel, Ernest;Castagliuolo, Ignazio;Bortolozzi, Roberta;Basso, Giuseppe;Viola, Giampietro [Journal of Medicinal Chemistry,2013,vol. 56,# 6,p. 2606 - 2618] Location in patent:supporting information