Acetamide, N-[2-[(1-oxido-2-pyridinyl)amino]ethyl]- (9CI) synthesis
- Product Name:Acetamide, N-[2-[(1-oxido-2-pyridinyl)amino]ethyl]- (9CI)
- CAS Number:193473-52-8
- Molecular formula:C9H13N3O2
- Molecular Weight:195.22
1001-53-2
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20295-64-1
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193473-52-8
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Yield:193473-52-8 45%
Reaction Conditions:
with sodium hydrogencarbonate
Steps:
V.a a
a N-Acetyl-N'-(1-oxo-2-pyridinyl)ethylenediamine A mixture of N-(acetyl)ethylenediamine (0.5 g, 5 mmol), 2-chloropyridine-N-oxide hydrochloride (1.6 g, 10 mmol), NaHCO3 (1.6 g, 19 mmol), and n-butanol (5 mL) was heated to 100° C. for 18 h. The mixture was then allowed to cool, and it was filtered and the filtrate concentrated. The resulting residue was purified by chromatography (silica gel, step gradient, 2%-10% CH3 OH/CH2 Cl2) to give the title compound as a pale yellow solid (0.40 g, 45%): MS (ES) m/e 196 [M+H]+.
References:
US6159964,2000,A