ChemicalBook CAS DataBase List (4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid

(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid synthesis

8synthesis methods

Product Name:(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid
CAS Number:196404-55-4
Molecular formula:C22H25NO6
Molecular Weight:399.44

(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylate

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(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid

196404-55-4
190 suppliers
$8.00/250mg

Yield:196404-55-4 92%

Reaction Conditions:

with methanol;sodium hydroxide at 20;

Steps:

6 Synthesis of benzooxazoline carboxylic acid
The above mention product 7 dissolved with ΜeOΗ, added dilute NaOH and stir at room temperature, TLC has been monitored after completion of the reaction and remove MeOH, the residue is diluted with Ac0Et / H20, static stratification. Into the aqueous phase added the AcOEt, and adjust the pH with dilute hydrochloric acid. The mixture is allowed to stand for separation, the organic phase has been separated, and the aqueous phase has been extracted with AcOEt, the combined organic phases are washed with water, dried over anhydrous MgS04, the solvent has been removed, and then obtained benzooxazoline carboxylic acid 8, yield of both steps is 92%.

References:

Jilin Pharmaceutical College;Fourth Military Medical University;Zhang Xiurong;Zhang Shengyong;Chen Ming;Jin Ying;Liang Chengwu;Chang Sheng;Li Xiaoye;Liu Xueying;Chen Weiping;Guan Shaoyu CN106632297, 2017, A Location in patent:Paragraph 0021

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