![](/CAS/GIF/106429-29-2.gif)
1H-Benzimidazol-5-ylmethanol synthesis
- Product Name:1H-Benzimidazol-5-ylmethanol
- CAS Number:106429-29-2
- Molecular formula:C8H8N2O
- Molecular Weight:148.16
![1H-Benzimidazole-5-carboxylic acid](/CAS/GIF/15788-16-6.gif)
15788-16-6
267 suppliers
$5.00/250mg
![1H-Benzimidazol-5-ylmethanol](/CAS/GIF/106429-29-2.gif)
106429-29-2
86 suppliers
$45.00/50mg
Yield:106429-29-2 77%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 65; for 48 h;Inert atmosphere;
Steps:
Preparation of compounds 7-10
Preparation of compounds 7-10
To a suspension of 2.0 g (12.3 mmol) of 1H-benzo[d]imidazole-5-carboxylic acid in 50 mL of dry THF, in inert atmosphere was added 983 mg (24,7 mmol) of LiAlH4 and stirred 48 h at 65 °C.
The reaction mixture was poured into EtOAc/EtOH and was filtered, by evaporation to dryness 1.4 g (77%) of compound 7 was obtained.
References:
Álvarez, Raquel;Gajate, Consuelo;Puebla, Pilar;Mollinedo, Faustino;Medarde, Manuel;Peláez, Rafael [European Journal of Medicinal Chemistry,2018,vol. 158,p. 167 - 183]
![Ethyl acetate](/CAS/GIF/141-78-6.gif)
141-78-6
607 suppliers
$20.50/250ml
![1H-Benzimidazole-5-carboxylic acid](/CAS/GIF/15788-16-6.gif)
15788-16-6
267 suppliers
$5.00/250mg
![1H-Benzimidazol-5-ylmethanol](/CAS/GIF/106429-29-2.gif)
106429-29-2
86 suppliers
$45.00/50mg
![Potassium sodium tartrate](/CAS/GIF/304-59-6.gif)
304-59-6
304 suppliers
$25.00/1kg
![1H-Benzimidazole-5-carboxylicacid,ethylester(9CI)](/CAS/GIF/58842-61-8.gif)
58842-61-8
28 suppliers
$85.00/250mg
![1H-Benzimidazol-5-ylmethanol](/CAS/GIF/106429-29-2.gif)
106429-29-2
86 suppliers
$45.00/50mg
![1H-Benzimidazole-5-carboxylicacid,ethylester(9CI)](/CAS/GIF/58842-61-8.gif)
58842-61-8
28 suppliers
$85.00/250mg
![1H-Benzimidazol-5-ylmethanol](/CAS/GIF/106429-29-2.gif)
106429-29-2
86 suppliers
$45.00/50mg
![1H-Benzimidazole, 5-(chloromethyl)- (9CI)](/CAS/GIF/774486-29-2.gif)
774486-29-2
3 suppliers
inquiry
![1H-Benzimidazol-5-ylmethanol](/CAS/GIF/106429-29-2.gif)
106429-29-2
86 suppliers
$45.00/50mg