ChemicalBook CAS DataBase List 1-(4-Bromophenyl)-2-phenylbenzimidazole

1-(4-Bromophenyl)-2-phenylbenzimidazole synthesis

7synthesis methods

Product Name:1-(4-Bromophenyl)-2-phenylbenzimidazole
CAS Number:760212-58-6
Molecular formula:C19H13BrN2
Molecular Weight:349.22

100953-52-4 Synthesis

100953-52-4
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98-88-4 Synthesis

98-88-4
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760212-58-6
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Yield:760212-58-6 82.2%

Reaction Conditions:

Stage #1: N¹-(4-bromophenyl)benzene -1,2 -diamine;benzoyl chloride in 1-methyl-pyrrolidin-2-one at 20 - 50; for 3.5 h;Inert atmosphere;
Stage #2: at 250; for 3 h;Inert atmosphere;

Steps:

1.3 third step

1000 ml three-neck bottle with electric stirring, Ar gas protection, adding the second step reaction product 35.5g (molecular weight 262, 0.13mol), benzoyl chloride 19.6g (molecular weight 140, specific gravity 1.212, 0.14mol), N-methyl Pyrrolidone (NMP) 350 ml, stirred at room temperature for 90 minutes, stirred at 50 ° C for 2 hrs, poured into 1000 ml of water, stirred, salted out and filtered off.The solid was heated to 130 ° C under the protection of Ar gas, and water was discharged (the water separator was installed in the device), and reacted at 250 ° C for 3 hours. The water was clearly separated and placed under room temperature with Ar gas protection. CHCl₃Extraction, separation by column chromatography, ethyl acetate elution afforded 37.3 g of pale white solid, molecular weight 348, HPLC 99.62%, yield 82.2%.

References:

CN104513206,2019,B Location in patent:Paragraph 0042; 0050-0052