1H-Carbazole, 6-bromo-2,3,4,9-tetrahydro-3-methyl- synthesis
- Product Name:1H-Carbazole, 6-bromo-2,3,4,9-tetrahydro-3-methyl-
- CAS Number:433725-14-5
- Molecular formula:C13H14BrN
- Molecular Weight:264.16
Yield:433725-14-5 87%
Reaction Conditions:
with acetic acid for 8 h;Reflux;Fischer Indole Synthesis;
Steps:
1. General procedure for compound 1a-b and 11
General procedure: A substituted phenyl hydrazine (1.00 g, 9.2 mmol) was added to the cyclohexanone (1.44 g, 9.2 mmol) in acetic acid (15 mL) in portion wise for 30 min. The mixture was then refluxed for 8 h and progress of reaction was monitored by thin layer chromatography. The reaction mixture was cooled and poured into crushed ice. The solid product was separated. Filter and dried. Recrystallized from methanol.
References:
Humne, Vivek T.;Naykode, Mahavir S.;Ghom, Monica H.;Lokhande, Pradeep D. [Tetrahedron Letters,2016,vol. 57,# 6,p. 688 - 691] Location in patent:supporting information
