1H-Imidazole-1-carboxamide, N-(phenylmethyl)- synthesis
- Product Name:1H-Imidazole-1-carboxamide, N-(phenylmethyl)-
- CAS Number:109844-65-7
- Molecular formula:C11H11N3O
- Molecular Weight:201.22
Yield:109844-65-7 87%
Reaction Conditions:
in tetrahydrofuran at 45; for 15 h;
Steps:
General Procedure for the Preparation of Carbamoyl Imidazole Compounds (2a-2e).
General procedure: To a solution of 1,1'-CDI (1.91 g, 11.8 mmol) in THF (20 mL), aniline (1 g, 10.74 mmol) was added. The reaction mixture was stirred at 45 °C until completion of the reaction for 15 h. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified by flash column chromatography on silica gel to afford the desired product 2a (1.54 g, 82%).
References:
Lee, Anna;Kim, Hee-Kwon;Thompson, David H. [Bulletin of the Korean Chemical Society,2016,vol. 37,# 2,p. 154 - 160]
