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ChemicalBook CAS DataBase List 1H-Imidazole-5-methanol,1-ethyl-(9CI)

1H-Imidazole-5-methanol,1-ethyl-(9CI) synthesis

2synthesis methods
-

Yield:215872-62-1 68%

Reaction Conditions:

Stage #1: 1-ethyl-2-mercapto-5-hydroxymethyl-imidazolewith dihydrogen peroxide;ortho-tungstic acid in ethanol;water at 40 - 80; for 2 h;
Stage #2: with sodium hydroxide in ethanol;water at 45; pH=Ca. 11;

References:

Hyok Chang, Jay;Woong Lee, Kyu;Hyun Nam, Do;Sup Kim, Won;Shin, Hyunik [Organic Process Research and Development,2002,vol. 6,# 5,p. 674 - 676]