1H-Imidazole-5-propanol,1-methyl-(9CI) synthesis
- Product Name:1H-Imidazole-5-propanol,1-methyl-(9CI)
- CAS Number:615578-60-4
- Molecular formula:C7H12N2O
- Molecular Weight:140.18
615578-68-2
0 suppliers
inquiry
615578-60-4
10 suppliers
inquiry
Yield:-
Reaction Conditions:
Stage #1:3-(3-methylimidazol-4-yl)propionic acid ethyl ester with lithium aluminium tetrahydride in tetrahydrofuran;diethyl ether at 0 - 21; for 2 h;
Stage #2: with sodium hydroxide;water in tetrahydrofuran;diethyl ether at 0; for 0.33 h;
Steps:
1M lithium aluminium hydride in diethyl ether (5. 75ml) in dry tetrahydrofuran (lOml) was stirred in an ice bath under nitrogen and a solution of intermediate A17 (1.047g) in dry THF (10ml) added dropwise. The resultant mixture was allowed to warm to 21 °C over 2h. The mixture was cooled in an ice bath and carefully treated (CARE effervescence) with water (0. 43ml), 1M sodium hydroxide (0. 29ml) and further water (0. 66ml). The mixture was stirred for 0.33h, filtered and the solid washed with further THF. The combined filtrates were evaporated under reduced pressure to give the desired product (0. 743g). IH- NMR (CDC13) 8 1.8-2. 0 (2H, m), 2.65 (2H, t), 3.56 (3H, s), 3.73 (2H, t), 6.78 (1H, s), 7.37 (1H, s).
References:
GLAXO GROUP LIMITED WO2003/87088, 2003, A2 Location in patent:Page/Page column 25
39021-62-0
200 suppliers
$35.00/1g
1099-45-2
363 suppliers
$6.00/5g
615578-60-4
10 suppliers
inquiry