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211805-71-9

1H-Inden-1-ol, 2,3-dihydro-4-(phenylmethoxy)- synthesis

4synthesis methods
86045-82-1 Synthesis
4-(benzyloxy)-2,3-dihydroinden-1-one

86045-82-1
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1H-Inden-1-ol, 2,3-dihydro-4-(phenylmethoxy)-

211805-71-9
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Yield:211805-71-9 1.8 g

Reaction Conditions:

with sodium tetrahydroborate in tetrahydrofuran;methanol at 0 - 20; for 4 h;

Steps:

42 Example 42
4-(Benzyloxy)-1-indanol

Sodium borohydride (0.64 g) was added to a methanol (20 mL) and THF (20 mL) solution of the compound (2.0 g) prepared in Example 41 at 0°C.
The reaction mixture was stirred at room temperature for 4 hours, and quenched with saturated ammonium chloride.
The reaction mixture was extracted with ethyl acetate, dried with anhydrous magnesium sulfate, filtered, and the filtrate was concentrated under vacuum to give the title compound (1.8 g) having the following physical properties.
1H-NMR (CDCl3):δ 7.44-7.32, 7.23-7.19, 7.04, 6.82, 5.27-5.25, 5.11, 3.08-3.05, 2.83-2.81, 2.52-2.48, 2.00-1.94, 1.69.

References:

EP3409658,2018,A1 Location in patent:Paragraph 0241