(1H-INDOL-6-YL)-CARBAMIC ACID TERT-BUTYL ESTER synthesis
- Product Name:(1H-INDOL-6-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- CAS Number:885273-73-4
- Molecular formula:C13H16N2O2
- Molecular Weight:232.28
5318-27-4
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Yield:885273-73-4 97%
Reaction Conditions:
with sodium hydrogencarbonate in tetrahydrofuran;water at 20; for 18 h;
Steps:
31 Synthesis of tert-Butyl 1H-indol-6-ylcarbamate (compound 64-2)
Synthesis of tert-Butyl 1H-indol-6-ylcarbamate (compound 64-2)[0000222] To a stirred solution of 1H-indol-6-amine (1.12 g, 8.5 mmol, 1 equiv) was added di-tert-butyl dicarbonate (1.95 g, 8.9 mmol, 1.05 equiv) in tetrahydrofuran (6 mL) . Saturated aqueous sodium bicarbonate (6 mL) was added and the reaction was stirred at room temperature for 18 hours. The layers were separated and the aqueous layer was extracted with ethyl acetate (3 x 5 mL) . The organic layers were combined, dried over sodium sulfate and concentrated under reduced pressure to give compound 64-2 as a white solid (2.2 g, 97% yield)
References:
WO2013/123215,2013,A2 Location in patent:Paragraph 0000222
19727-83-4
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4769-96-4
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496-15-1
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