1H-Indole-3-ethanol, β-1H-indol-3-yl- synthesis

12synthesis methods

Product Name:1H-Indole-3-ethanol, β-1H-indol-3-yl-
CAS Number:95331-90-1
Molecular formula:C18H16N2O
Molecular Weight:276.34

1H-Indole-3-acetic acid, α-1H-indol-3-yl-, ethyl ester

3616-48-6
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95331-90-1
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Yield:95331-90-1 74%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at 0 - 20; for 3 h;

Steps:

3.1 Example 3: Compounds 2,2-bis(1H-indol-3-yl)ethanol (I-5) and 2,2-bis(1H-indol-3-yl)ethyl acetate (I- 6) Synthesis:

The first step: 0, while stirring, slowly add lithium aluminum tetrahydrogen (0.57g, 15mmol) to tetrahydrofuran (50mL), stir for 10min, slowly add ester I-1 (1.59g, 5mmol), the reaction solution is natural The temperature was raised to room temperature and reacted for 3 hours. Water (10 mL) was slowly added dropwise to the reaction system to quench the reaction. Add diatomaceous earth to suction filtration, wash the filter cake with ethyl acetate, combine the organic phases and dry with anhydrous Na2SO4, suction filtration, concentrate, and column chromatography to obtain light yellow oily compound I-5 (1.02g, 74%);

References:

CN113040151,2021,A Location in patent:Paragraph 0027-0028