1H-Indole-4-carboxamide(9CI) synthesis

Yield:1670-86-6 92%

Reaction Conditions:

with water;C₃₃H₂₈F₃N₅O₃Ru⁽¹⁺⁾*Cl^(1-) at 60; for 0.583333 h;Catalytic behavior;Sonication;

Steps:

2.5 General Procedure for the Catalytic Hydration ofNitriles.

General procedure: The corresponding nitrile (1.0mmol), water (5.0 mL)and the ruthenium(III) catalyst 5a (0.1 mol%) were introducedinto a flask and the reaction mixture was sonicated at 60 °C forthe indicated time. The course of the reaction was monitored byTLC analysis. Once the reaction finished, the hot mixture waspassed through a filter paper (to remove the catalyst), allowedto reach room temperature, and then kept in an ice bath for 2 h.This led to the crystallization of the corresponding primaryamide, which was separated, recrystallized from hot water,washed with n-hexane (3 5.0 mL) and vacuum-dried. Theidentity of the amides was assessed by comparison of theirNMR spectroscopic data with those reported in the literature.

References:

Arafa, Wael Abdelgayed Ahmed [Bulletin of the Chemical Society of Japan,2020,vol. 93,# 9,p. 1056 - 1064]