1H-Isoindole-4-carboxaMide, 2,3-dihydro-3-oxo- synthesis

Yield:-

Reaction Conditions:

with ammonia in tetrahydrofuran;water at 20; for 0.5 h;

Steps:

16
Compound 16d was dissolved in THF and treated with concentrated ammonium hydroxide at room temperature for 30 min to give 3-oxo-2,3-dihydro-lH-isoindole-4- carboxylic acid amide 16e ¹H NMR (300 MHz, DMSO-^₆) 4.64 (s, 2H), 7.84 (t, J = 7.6 Hz, IH), 7.92 (d, J = 7 Hz, IH), 8.17 (d, J = 7.7 Hz, IH), 10.15 (broad s, IH); MS (ESI) m/z: 177 (MH⁺). )

References:

Location in patent:Page/Page column 68-69