1H-pyrazole, 1-ethyl-4-nitro- synthesis
- Product Name:1H-pyrazole, 1-ethyl-4-nitro-
- CAS Number:58793-45-6
- Molecular formula:C5H7N3O2
- Molecular Weight:141.13
Yield:58793-45-6 92%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20;
Steps:
5 Synthesis of Compound 5.1.
Synthesis of Compound 5.1. Into a 250-mL round-bottom flask was placed 4- nitro-lH-pyrazole (2 g, 17.69 mmol, 1.00 equiv), potassium carbonate (7.33 g, 53.04 mmol, 3.00 equiv), iodoethane (4.22 g, 27.06 mmol, 2.00 equiv) in N,N-dimethylformamide (50 mL). The reaction was stirred overnight at room temperature. Then it was extracted with 3 x 500 mL of ethyl acetate and the organic layers combined and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with ethyl acetate/petroleum ether (1 : 10). This afforded 2.3 g (92%) of 5.1 as a white solid.
References:
WO2017/4134,2017,A1 Location in patent:Paragraph 00289
