1H-Pyrazole-4-carboxamide,3-amino-1-methyl-(9CI) synthesis

Yield:89181-79-3 83%

Reaction Conditions:

with sulfuric acid at 0 - 20; for 5 h;

Steps:

4.3. General procedure for synthesis of 3-amino-1-(alkyl or arylalkyl)-1H-pyrazole-4-carboxamide (11-14)

General procedure: Carbonitriles 7-10 (0.03 mol) was dissolved in 7 mL concdH2SO4 at 0 C and stirred at room temperature for 5 h. Then thereaction mixture was poured into ice cold water and neutralizedto pH 7 with 28% NH3 solution. The white precipitate was formedwhich was further washed with cold water and dried undervacuum.

References:

Venkatesan, Gopalakrishnan;Paira, Priyankar;Cheong, Siew Lee;Vamsikrishna, Kosaraju;Federico, Stephanie;Klotz, Karl-Norbert;Spalluto, Giampiero;Pastorin, Giorgia [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 5,p. 1751 - 1765]