1H-Pyrazole-5-ethanol, 1-phenyl- synthesis
1synthesis methods
- Product Name:1H-Pyrazole-5-ethanol, 1-phenyl-
- CAS Number:1044856-44-1
- Molecular formula:C11H12N2O
- Molecular Weight:188.23
Yield:1044856-44-1 75%
Reaction Conditions:
Stage #1: 1-phenylpyrazolewith n-butyllithium in tetrahydrofuran;hexane at -78; for 2 h;
Stage #2: ethyleneglycol sulfate in tetrahydrofuran;hexane at 20; for 26 h;
Stage #3: with sulfuric acid in tetrahydrofuran;hexane; for 24 h;Heating;Further stages.;
References:
Schlaeger, Torsten;Oberdorf, Christoph;Tewes, Bastian;Wuensch, Bernhard [Synthesis,2008,# 11,p. 1793 - 1797]