ChemicalBook CAS DataBase List 1H-PYRAZOLO[3,4-B]PYRIDIN-5-AMINE

1H-PYRAZOLO[3,4-B]PYRIDIN-5-AMINE synthesis

2synthesis methods

Product Name:1H-PYRAZOLO[3,4-B]PYRIDIN-5-AMINE
CAS Number:942185-01-5
Molecular formula:C6H6N4
Molecular Weight:134.14

63572-73-6 Synthesis

63572-73-6
78 suppliers
$50.00/100mg

942185-01-5
68 suppliers
$18.00/100mg

Yield: 89%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in tetrahydrofuran;ethanol for 15 h;

Steps:

5.2 Step 2:
10 % Palladium on carbon (40 mg) was added to a solution of 5-nitro-1H-pyrazolo[3,4-b]pyridine (A) (308 mg, 1.876 mmol) in ethanol and tetrahydrofuran and the mixture was charged with H₂ (gas). After stirring the reaction mixture for 15 h, the mixture was filtered using celite and purified by column chromatography. The desired product 1H-pyrazolo[3,4-b]pyridin-5-amine (B) (73 mg) was obtained as 89 % yield.

References:

GRÜNENTHAL GMBH;FRANK, Robert;CHRISTOPH, Thomas;LESCH, Bernhard;LEE, Jeewoo WO2013/13816, 2013, A1 Location in patent:Page/Page column 73; 74

Carbamic acid, N-[1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazolo[3,4-b]pyridin-5-yl]-, 1,1-dimethylethyl ester

1186608-67-2
0 suppliers
inquiry

942185-01-5
68 suppliers
$18.00/100mg

References