![](/CAS/GIF/952182-02-4.gif)
1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID synthesis
- Product Name:1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID
- CAS Number:952182-02-4
- Molecular formula:C7H5N3O2
- Molecular Weight:163.13
![1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 1-[(4-methoxyphenyl)methyl]-, ethyl ester](/CAS/20210111/GIF/1086423-59-7.gif)
1086423-59-7
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![1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID](/CAS/GIF/952182-02-4.gif)
952182-02-4
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$85.00/250MG
Yield: 80%
Reaction Conditions:
with trifluoroacetic acid at 80; for 4 h;
Steps:
4.5 Intermediate 4: 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid
Step 5. Ethyl 1-(4-methoxybenzyl )-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (4.4 g, 1 4 mmol) was dissolved in TFA (1 58 mL) and heated to 80 °C. The mixture was stirred at 80 "C for 4 h, then was concentrated to dryness. The residue was poured into ice water, then aqueous NaOH solution (2 M) was added until the pH was approximately 14 The solid formed was removed by filtration, and the aqueous layer was washed with ethyl acetate. To the aqueous layer was added concentrated HCl was added until the pH was approximately 7. The resulting precipitate was collected by vacuum filtration and dried under vacuum to afford the title compound as a white solid (2. 1 g, 80%). 1H NMR (400 MHz, DMSO-d6) δ 1 4.38- 13 62 (br, 1 H), 9.07 (d, J = 1 .6 Hz, 1 H), 8.81 (d, J = 1 .6 Hz, 1 H), 8.32 (s, 1 H). MS (m/z, ESI+): 1 64 [M+H]
References:
Location in patent:Page/Page column 131; 133
![Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate](/CAS/GIF/1196156-42-9.gif)
1196156-42-9
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$110.00/50mg
![1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID](/CAS/GIF/952182-02-4.gif)
952182-02-4
87 suppliers
$85.00/250MG
![ethyl 4-hydroxy-1-(4-Methoxybenzyl)-1H-
pyrazolo[3,4-b]pyridine-5-carboxylate](/CAS/20150408/GIF/227617-15-4.gif)
227617-15-4
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![1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID](/CAS/GIF/952182-02-4.gif)
952182-02-4
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![ethyl 4-chloro-1-(4-Methoxybenzyl)-1H-
pyrazolo[3,4-b]pyridine-5-carboxylate](/CAS/20150408/GIF/227617-16-5.gif)
227617-16-5
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![1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID](/CAS/GIF/952182-02-4.gif)
952182-02-4
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$85.00/250MG
![5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE](/CAS/GIF/875781-17-2.gif)
875781-17-2
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$7.00/250mg
![1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID](/CAS/GIF/952182-02-4.gif)
952182-02-4
87 suppliers
$85.00/250MG