1H-Pyrrole-2-carboxamide,1-amino-5-methyl-(9CI) synthesis
- Product Name:1H-Pyrrole-2-carboxamide,1-amino-5-methyl-(9CI)
- CAS Number:310430-93-4
- Molecular formula:C6H9N3O
- Molecular Weight:139.16
310430-92-3
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Yield:310430-93-4 60%
Reaction Conditions:
with potassium hydroxide;water at 20 - 50;
Steps:
11.D
D. 1-Amino-2-aminocarbonyl-5-methyl-pyrrole To a solution of 1.1 g (20 mmol) of KOH in 2.5 ml of water was added 100 mg (0.82 mmol) of Compound C. The suspension was stirred overnight at rt and heated at 50° C. for 4 hrs. The resulting precipitate was removed by filtration. The filter cake was dissolved in ethyl acetate, the solution was dried (MgSO4) and the solvent removed to give 58 mg of Compound D as a yellow solid. The aqueous filtrate was extracted 3* with ethyl acetate. The combined extracts were dried (MgSO4) and the solvent removed to give an additional 11 mg of Compound D as a yellow solid (total 69 mg, 60%).
References:
US6982265,2006,B1 Location in patent:Page/Page column 26-27
636-41-9
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