ChemicalBook CAS DataBase List (1R)-(+)-(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID

(1R)-(+)-(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID synthesis

6synthesis methods

Product Name:(1R)-(+)-(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID
CAS Number:66254-56-6
Molecular formula:C4H12NO3P
Molecular Weight:153.12

18108-24-2 Synthesis

18108-24-2
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(1S)-(-)-(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID

66254-55-5
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$688.84/250MG

(1R)-(+)-(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID

66254-56-6
35 suppliers
$178.08/250MG

Yield:40 % ee

Reaction Conditions:

with Trigonopsis variabilis in water at 20; for 72 h;Resolution of racemate;Microbiological reaction;Enzymatic reaction;

Steps:

1.1 General:

2.1.1
1-Amino-2-methylpropanephosphonic acid (Val^P)
³¹P NMR δ (ppm): 13.44.
¹H NMR δ (ppm): 0.95 (dd, J = 6.9 Hz, 6H, (CH₃)₂CH), 2.00-2.15 (m, 1H, (CH₃)₂CH), 2.94 (dd, J = 6.3 Hz, 1H, CHP).

References:

Kozyra, Kinga;Brzezinska-Rodak, Malgorzata;Klimek-Ochab, Magdalena;Zymanczyk-Duda, Ewa [Journal of Molecular Catalysis B: Enzymatic,2013,vol. 91,p. 32 - 36]