ChemicalBook CAS DataBase List (1R,6S)-8-Boc-3,8-diazabicyclo[4.2.0]octane

(1R,6S)-8-Boc-3,8-diazabicyclo[4.2.0]octane synthesis

4synthesis methods

Product Name:(1R,6S)-8-Boc-3,8-diazabicyclo[4.2.0]octane
CAS Number:370881-22-4
Molecular formula:C11H20N2O2
Molecular Weight:212.29

3,8-Diazabicyclo[4.2.0]octane-3,8-dicarboxylic acid, 8-(1,1-dimethylethyl) 3-(phenylmethyl) ester, (1R,6S)-

923957-48-6
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(1R,6S)-8-Boc-3,8-diazabicyclo[4.2.0]octane

370881-22-4
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Yield:370881-22-4 60%

Reaction Conditions:

palladium in methanol;

Steps:

42.F tert-butyl (cis)-3,8-diazabicyclo[4.2.0]octane-8-carboxylate

EXAMPLE 42F tert-butyl (cis)-3,8-diazabicyclo[4.2.0]octane-8-carboxylate The product of Example 42E (190 mg, 0.50 mmol) in methanol (10 mL) was treated with 10% palladium on carbon and the mixture was stirred under H₂ (1 atm) at 40-45° C. for 4 hours. The mixture was filtered and the filtrate concentrated to provide the title compound (60 mg, 60 % yield). MS (DCI/NH₃) m/z 213 (M+H)⁺.

References:

US2002/19388,2002,A1

3,8-Diazabicyclo[4.2.0]octane-8-carboxylic acid, 3-(2,2,2-trifluoroacetyl)-, 1,1-dimethylethyl ester, (1R,6S)-

851526-79-9
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370881-22-4
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3,8-Diazabicyclo[4.2.0]octane-3-carboxylic acid, 8-[(2-nitrophenyl)sulfonyl]-, 1,1-dimethylethyl ester, (1R,6S)-

370882-98-7
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370881-22-4
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3,8-Diazabicyclo[4.2.0]octane-3-carboxylic acid, 8-[(2-nitrophenyl)sulfonyl]-, phenylmethyl ester, (1R,6S)-

923956-63-2
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370881-22-4
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References