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ChemicalBook CAS DataBase List (1S,2S)-2-Methylcyclopropane-1-carboxylic acid

(1S,2S)-2-Methylcyclopropane-1-carboxylic acid synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: conc. H2SO4
2: 1) LDA, 2) AgCl / 1) THF, -78 deg C -> 0 deg C, 3 h, 2) -78 deg C, 1 h, then rt, 15 h
3: aq. NaOH / Ambient temperature; pig liver esterase, pH 7.5-8.0 (phosphate buffer)

References:

Walser, Paula;Renold, Peter;N'Goka, Victor;Hosseinzadeh, Fatemeh;Tamm, Christoph [Helvetica Chimica Acta,1991,vol. 74,# 8,p. 1941 - 1952]

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