(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane synthesis
- Product Name:(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane
- CAS Number:132339-20-9
- Molecular formula:C5H10N2
- Molecular Weight:98.15
455-15-2
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Yield:132339-20-9 85%
Reaction Conditions:
at 150; for 2 h;
Steps:
9
Intermediate 9; (S)-l-(4-Methanesulfonylphenyl)-3-methylpiperazine; A mixture of l-fluoro-4-methanesulfonylbenzene (0.74g, 4.25mmol) and (S)-2-methyl piperazine (2.13g, 21.3mmol) was heated at 150 0C for 2h. The reaction was cooled and DCM and water was added. The two layers were separated and the organic phase washed with water, brine, dried (MgSO4) and the solvent removed in vacuo to afford the title compound (0.916g, 85%): RT = 1.64 min; m/z (ES+) = 255.1 [M+ H]+
References:
WO2007/3964,2007,A1 Location in patent:Page/Page column 40