2-(1-CHLOROETHYL)QUINAZOLIN-4(3H)-ONE synthesis

3synthesis methods

Product Name:2-(1-CHLOROETHYL)QUINAZOLIN-4(3H)-ONE
CAS Number:137225-34-4
Molecular formula:C10H9ClN2O
Molecular Weight:208.64

7623-09-8
276 suppliers
$40.00/10g

Benzenecarboximidic acid, 2-amino- (9CI)

28144-70-9
6 suppliers
inquiry

137225-34-4
16 suppliers
inquiry

Yield:137225-34-4 74%

Reaction Conditions:

at 80; for 1 h;

Steps:

2.2.1. General procedure for the synthesis of 2-benzopyrimidinones 2

General procedure: A mixture of 2-aminobenzamide 1 (1 g, 4.9 mmol) and acyl chloride (1 mL, 5.8 mmol) was heated at 80 °C for 1 hour on steam bath.After the reaction was completed, the mixture was cooled to room temperature and neutralized with Na 2 CO 3 (10%) solution. The precipitate was collected and recrystallized from ethanol.

References:

Chortani, Sarra;Horchani, Mabrouk;Znati, Mansour;Issaoui, Noureddine;Jannet, Hichem Ben;Romdhane, Anis [Journal of Molecular Structure,2021,vol. 1230,art. no. 129920]

4H-3,1-Benzoxazin-4-one, 2-(1-chloroethyl)-

89441-13-4
0 suppliers
inquiry

137225-34-4
16 suppliers
inquiry

References

2-[(2-Chloropropanoyl)amino]benzoic acid

137225-33-3
6 suppliers
inquiry

137225-34-4
16 suppliers
inquiry

References