2-(1-ETHOXYPROPYLIDENE)MALONONITRILE synthesis

Yield:35260-96-9 97%

Reaction Conditions:

in acetic anhydride; for 15 h;Reflux;

Steps:

7.a; 4

To a stirred solution of malononitrile (2.64 g, 40.0 mmol) in acetic anhydride (9 mL) was added 1 ,1 , 1 -triethoxypropane (8.04 g, 40.0 mmol). The solution was stirred for 15 h at reflux, cooled, and poured into water. The mixture was extracted with ether, and the organic extract was washed with aqueous NaHC0₃ and then brine. The solution was dried (MgS0₄) and concentrated under reduced pressure to afford a solid identified as 2-(l -ethoxypropylidene)malononitrile (5.80 g, 97%). The procedure was adapted from J Med. Chem. 2004, 47, 5894-591 1 .

References:

WO2011/42475,2011,A1 Location in patent:Page/Page column 39