2-(1-nitronaphthalen-2-yl)acetonitrile synthesis

9synthesis methods

Product Name:2-(1-nitronaphthalen-2-yl)acetonitrile
CAS Number:89278-00-2
Molecular formula:C12H8N2O2
Molecular Weight:212.2041

86-57-7 Synthesis

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Yield:89278-00-2 87%

Reaction Conditions:

with potassium tert-butylate in N,N-dimethyl-formamide at -24; for 2.5 h;

Steps:

Typical procedure for synthesis of nitriles:

General procedure: 1 equivalent of the aromatic nitro compound and 1.2 equivalents of4-chlorophenoxyacetonitrile were dissolved in anhydrous DMF and slowly added toa solution of 2.3 equivalents of potassium tert-butoxidedissolved in DMF at -24 °C. The color of the mixture turned to deep purple, andit was stirred at -24 °C for further 2.5 h. Then the reaction mixture waspoured into 200 ml of ice cold 5 % HCl. A brown precipitate was formed. Themixture was extracted with ethyl acetate (EA) and the product purified by flashchromatography.

References:

Schlosser, Joachim;Johannes, Eugen;Zindler, Melanie;Lemmerhirt, Jan;Sommer, Benjamin;Schütt, Martin;Peifer, Christian [Tetrahedron Letters,2015,vol. 56,# 1,p. 89 - 94] Location in patent:supporting information

86-57-7 Synthesis

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$14.00/5g