ChemicalBook CAS DataBase List 2-(1-Piperazinyl)pyrimidine

2-(1-Piperazinyl)pyrimidine synthesis

7synthesis methods

Product Name:2-(1-Piperazinyl)pyrimidine
CAS Number:20980-22-7
Molecular formula:C8H12N4
Molecular Weight:164.21

110-85-0 Synthesis

110-85-0
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$5.00/5 g

1722-12-9 Synthesis

1722-12-9
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$10.00/1g

20980-22-7
349 suppliers
$5.00/1g

Yield:20980-22-7 88%

Reaction Conditions:

with potassium carbonate in water at 35 - 65;

Steps:

4.2.3. Synthetic procedure of intermediates 4-(4,6-disubstitutedpyrimidin-2-yl)piperazine (18a-c)
General procedure: 2-Chloro-4,6-disubstituted-pyrimidines 17 were prepared bythe reaction of the diazoniumsalts of 4,6-disubstituted-pyrimidin-2-amines (16) with concentrated hydrochloric acid and ZnCl2 [35].Compound 18 was prepared according to literature [32], and themethod was improved. To a stirred solution of piperazine(45 mmol) and K2CO3 (16.5 mmol) in water (20 mL) was addedchloropyrimidine 17 (18 mmol) in small portions at 50e65 C. Themixture was stirred for 1 h at 60e65 C and cooled to 35 C. Theyellowsolid, 1,4-bispyrimidylpiperazine byproduct, was filtered off,and the filtrate was then extracted three times with chloroform,dried over Na2SO4, and evaporated in vacuum to give compound 18,which was used for the following reactions without further purification. 18a: yellow oil, yield 88%.

References:

Wang, Bao-Lei;Shi, Yan-Xia;Zhang, Shu-Jun;Ma, Yi;Wang, Hong-Xue;Zhang, Li-Yuan;Wei, Wei;Liu, Xing-Hai;Li, Yong-Hong;Li, Zheng-Ming;Li, Bao-Ju [European Journal of Medicinal Chemistry,2016,vol. 117,p. 167 - 178]

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