ChemicalBook CAS DataBase List 2-[2-(2-Aminophenoxy)ethoxy]-4-methyl-benzenamine

2-[2-(2-Aminophenoxy)ethoxy]-4-methyl-benzenamine synthesis

6synthesis methods

Product Name:2-[2-(2-Aminophenoxy)ethoxy]-4-methyl-benzenamine
CAS Number:96331-95-2
Molecular formula:C15H18N2O2
Molecular Weight:258.32

4-METHYL-1-NITRO-2-[2-(2-NITROPHENOXY)ETHOXY]-BENZENE

96315-08-1
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2-[2-(2-Aminophenoxy)ethoxy]-4-methyl-benzenamine

96331-95-2
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$80.00/10mg

Yield:96331-95-2 95%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in DMF (N,N-dimethyl-formamide); under 2068.65 Torr; for 18 h;

Steps:

4

Example 4. Preparation of 1- (2 -AMINO-5 -METHYLPHENOXY)-2- (2"-AMINOPHENOXY) ethane (9). Compound 8 (24.0 g, 75 mmol) was hydrogenated over 10% Pd/C (1.5 G) in DMF (250 mL) at 40 psi for 18 h. The mixture was filtered from catalyst through a CELITE pad on a fritted glass filter. The filtrate was evaporated and ether (50 mL) was added. The product was filtered, washed with ether and dried to give compound 9,18. 0 g (95%) as a brown solid.

References:

WO2005/16874,2005,A2 Location in patent:Page/Page column 56