2-(2,3-DIHYDRO-1H-INDOL-1-YL)ETHANAMINE synthesis
- Product Name:2-(2,3-DIHYDRO-1H-INDOL-1-YL)ETHANAMINE
- CAS Number:46006-95-5
- Molecular formula:C10H14N2
- Molecular Weight:162.23
496-15-1
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2576-47-8
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46006-95-5
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Yield:46006-95-5 70%
Reaction Conditions:
Stage #1: 1-indoline;2-bromoethylamine hydrobromidewith sodium hydrogencarbonate in water at 95; for 2.75 h;Reflux;
Stage #2: with sodium hydroxide in water at 20;
Steps:
Method B. Synthesis of 1-(2-aminoethyl)indoline (2).
A hot solution of NaHCO3 (10.08 g, 0.12 mol) in water (45 mL) was added to a hot (~95 ° C) mixture of indoline (11.9 g, 0.1 mol), 2-bromoethylamine hydrobromide ((24.6 g, 0.12 mol), and water (12 mL) with stirring over 30 min. The reaction mixture was kept for~15 min at 95 ° C in a bath, then refluxed for ~2.5 h until reaction reached completion, and worked-up similarly to method A.
References:
Vasilyeva;Vorobyeva;Osipov [Russian Chemical Bulletin,2016,vol. 65,# 9,p. 2211 - 2215][Izv. Akad. Nauk, Ser. Khim.,2016,# 9,p. 2211 - 2215,5]
13708-58-2
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46006-95-5
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![Ethanone, 1-[1-(2-aminoethyl)-1H-indol-3-yl]-2,2,2-trifluoro-](/CAS/20210305/GIF/75626-11-8.gif)
75626-11-8
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13708-58-2
32 suppliers
$90.00/50mg
46006-95-5
44 suppliers
$45.00/50mg
