ChemicalBook CAS DataBase List 2-(2,3-Dimethylphenyl)acetonitrile

2-(2,3-Dimethylphenyl)acetonitrile synthesis

4synthesis methods

Product Name:2-(2,3-Dimethylphenyl)acetonitrile
CAS Number:76574-43-1
Molecular formula:C10H11N
Molecular Weight:145.2

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Yield:76574-43-1 99%

Reaction Conditions:

with sodium hydroxide in water;

Steps:

1 Preparation of dimethylbenzyl cyanide

EXAMPLE 1 Preparation of dimethylbenzyl cyanide A reactor was charged with 1416 g of sodium hydroxide solution, 33% strength, and 425 g of caustic soda. 6 g of trioctylamine was then added to this solution, and then 400 g of benzyl cyanide and 380 g of chloromethane were reacted in this mixture at from 20° C. to 40° C. with stirring at superatmospheric pressure. After the internal pressure had dropped to below 0.5 bar, the residual pressure was released. 2000 ml of water were then added, and the mixture was briefly stirred and allowed to settle, and then the phases were separated. The organic phase was distilled under reduced pressure to give 485.5 g of pure dimethylbenzyl cyanide having a content of more than 99%, as determined by gas chromatography "GC".

References:

US6143896,2000,A