2,2,3-Trimethyl-2,3-Dihydrobenzofuran-6-Ol synthesis

Yield:31354-04-8 66%

Reaction Conditions:

resin (Amberlyst-15)

Steps:

R.2 2,3-Dihydro-6-hydroxy-2,2,3-trimethylbenzofuran (a precursor of compound No. 6)

REFERENTIAL EXAMPLE 2 2,3-Dihydro-6-hydroxy-2,2,3-trimethylbenzofuran (a precursor of compound No. 6) A 100 ml three-necked flask equipped with a condenser and a thermometer was charged with 11 g (0.1 mole) of resorcinol, 8.6 g (0.1 mole) of isopropyl methyl ketone and 1.3 g (12% by weight based on resorcinol) of a cation exchange resin (Amberlyst-15) as a catalyst. The mixture was stirred at 100° C. in a nitrogen atmosphere for 10 hours. After cooling, the catalyst was separated by filtration, and the residue was purified by column chromatography to give 11.8 g (yield 66%) of the desired productg as colorless needle-like crystals. Melting point: 67.5° C.

References:

US4838924,1989,A