2-(2,4-Difluorobenzoyl)benzoic acid synthesis
- Product Name:2-(2,4-Difluorobenzoyl)benzoic acid
- CAS Number:135030-72-7
- Molecular formula:C14H8F2O3
- Molecular Weight:262.21
85-44-9
755 suppliers
$9.00/5g
372-18-9
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$9.00/1g
79-34-5
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$10.00/5g
135030-72-7
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$499.80/5MG
Yield:135030-72-7 86.5 g (75%)
Reaction Conditions:
with hydrogenchloride
Steps:
2-(2,4-Difluorobenzoyl)benzoic acid
2-(2,4-Difluorobenzoyl)benzoic acid To a mixture of phthalic anhydride (64.8 g, 438 mmol), tetrachloroethane (600 mL) and 1,3-difluorobenzene (100 g, 877 mmol) was added anhydrous A1C13 (141 g, 964 mmol) over 20 minutes while maintaining the reaction temperature below 40° C. The temperature was increased to 90° C. for 2 hours, the reaction mixture was cooled and poured into ice/6N HCl. The mixture was extracted with ether (2*1.2 L) and the combined ether extracts were dried over Na2 SO4. The solvent was removed in vacuo and the residue was recrystallized from hot ethyl acetate to afford 86.5 g (75%) of 2-(2,4-difluorobenzoyl)benzoic acid, m.p. 129°-131 ° C.
References:
US5380721,1995,A