ChemicalBook CAS DataBase List 2,2,6,6-Tetramethyl-3,5-heptanedione

2,2,6,6-Tetramethyl-3,5-heptanedione synthesis

8synthesis methods

Product Name:2,2,6,6-Tetramethyl-3,5-heptanedione
CAS Number:1118-71-4
Molecular formula:C11H20O2
Molecular Weight:184.28

Methyl pivalate and formamide could be used as starting materials to synthesize 2,2,6,6-Tetramethyl-3,5-heptanedione.

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Yield:1118-71-4 95%

Reaction Conditions:

with (triphenylphosphine)gold(I) chloride;water;silver trifluoromethanesulfonate in methanol at 25; for 12 h;

Steps:

31 Example 31:
Add 0.2mmol α-alkynyl ketones in a reaction tube 10mL R¹is tert-butyl, R²is tert-butyl, 0.005mmol of PPh₃AuCl, 0.006mmol of AgOTf, 2mmol of H₂O, 1mL of methanol, stirred for 12h in air atmosphere at 25 °C. After completion of the reaction, rotary evaporation, product was separated by column chromatography to give the following: 2,2,6,6-tetramethyl-3,5-heptane dione (2,2,6,6-tetramethylheptane-3,5-dione ). Oily liquid, yield 95%.

References:

Wenzhou University;Xia Yuanzhi;Kuang Jinqiang;Zhou Tao;Chen Jianhui CN109776293, 2019, A Location in patent:Paragraph 0236-0241

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