2-(2,6-Dichlorophenoxy)propanoic acid synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
2: water; sodium hydroxide / tetrahydrofuran / 3 h / 80 °C / Inert atmosphere

References:

Gorla, Suresh Kumar;Kavitha, Mandapati;Zhang, Minjia;Chin, James En Wai;Liu, Xiaoping;Striepen, Boris;Makowska-Grzyska, Magdalena;Kim, Youngchang;Joachimiak, Andrzej;Hedstrom, Lizbeth;Cuny, Gregory D. [Journal of Medicinal Chemistry,2013,vol. 56,# 10,p. 4028 - 4043]