2-(2,6-Difluorophenyl)-N-Methoxy-N-Methylacetamide synthesis
- Product Name:2-(2,6-Difluorophenyl)-N-Methoxy-N-Methylacetamide
- CAS Number:946402-24-0
- Molecular formula:C10H11F2NO2
- Molecular Weight:215.2
85068-28-6
228 suppliers
$8.00/1g
6638-79-5
561 suppliers
$6.00/25g
946402-24-0
12 suppliers
$65.00/5mg
Yield:946402-24-0 92%
Reaction Conditions:
Stage #1: 2,6-difluorophenylacetic acidwith 1,1'-carbonyldiimidazole in tetrahydrofuran; for 1 h;Inert atmosphere;Cooling with ice;
Stage #2: N,O-dimethylhydroxylamine*hydrochloridewith N-ethyl-N,N-diisopropylamine in tetrahydrofuran;N,N-dimethyl-formamide; for 24 h;Inert atmosphere;
References:
Chou, Chun-Ming;Tung, Yu-Wen;Lin, Meng-I;Chan, Diana;Phakhodee, Wong;Isobe, Minoru [Heterocycles,2012,vol. 86,# 2,p. 1323 - 1339]