2-(2,6-DIMETHYLPHENOXY)ACETOHYDRAZIDE synthesis
- Product Name:2-(2,6-DIMETHYLPHENOXY)ACETOHYDRAZIDE
- CAS Number:64106-78-1
- Molecular formula:C10H14N2O2
- Molecular Weight:194.23
6279-47-6
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64106-78-1
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Yield:64106-78-1 72%
Reaction Conditions:
with hydrazine hydrate in ethanol;Reflux;
Steps:
Synthesis of 2-(4-nitrophenoxy)acetohydrazide 3a.
General procedure: To a solution of 2a (0.1 mol) in ethanol (40mL) hydrazine hydrate(0.1 mol) was added dropwisely. Then, the mixture was heated to refluxing temperature and reacted for 4-5 h. When the reaction was completed, the mixture was poured into ice water (100 mL). The precipitated solid was filtrated, washed and dried. Then the crude product was recrystallized by using the mixture of DMF and H2O (1:1) to give 3a as gray solid in 85% yield, mp 138-140°C. All the other compounds are synthesized the same procedure (Scheme 1).
References:
He, Hai-Qin;Liu, Xing-Hai;Weng, Jian-Quan;Tan, Cheng-Xia [Letters in drug design and discovery,2017,vol. 14,# 2,p. 195 - 200]
576-26-1
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